Qs in the Nucleus

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Qs in the Nucleus

The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating SCA7-induced retinal degeneration to a disru...

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ژورنال

عنوان ژورنال: Neuron

سال: 2001

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(01)00435-4